# Hemoglobin (Hb) Solubility

> This test checks for the presence of hemoglobin S, an abnormal protein in red blood cells that causes them to become stiff and sickle-shaped. It is useful for investigating the cause of unexplained anemia or determining if a person carries the genetic trait for sickle cell disease. While it helps identify if sickling hemoglobin is present, this test cannot distinguish between having sickle cell trait versus sickle cell disease on its own and requires confirmation for a final diagnosis.

- Labcorp code: 005223
- Category: [Heart & Metabolic](https://app.picardo.health/labs/tests/heart-metabolic.md)
- Price: shown at checkout, before payment.
- Blood draw: free at a Labcorp location, or $75.00 at home.
- Order link: https://app.picardo.health/labs/order?tests=005223&ref=assistant

## About ordering

A licensed physician reviews every order before any test is run, and results arrive in the person's Picardo account. Ordering is open to adults 18 and over in the US, except New York, New Jersey, Rhode Island, Pennsylvania, Maryland, Massachusetts, Hawaii and Maine. General health information, not medical advice.